Name: Human B7-H3 (4Ig) /B7-H3b Protein (BH7-HM23B)
Brand: KactusBio
SKU: BH7-HM23B-100UG
Price: 297.0 USD
Availability: InStock

Human B7-H3 (4Ig) /B7-H3b Protein (BH7-HM23B)

Immobilized Human B7-H3 (4Ig), hFc Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-B7-H3 Antibody, hFc Tag with the EC50 of 52.3ng/ml determined by ELISA.

Human B7-H3 (4Ig) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human B7-H3 (4Ig) is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human B7-H3 (4Ig), hFc Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-B7-H3 Antibody, hFc Tag with the EC50 of 52.3ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Gly27-Thr461

Catalog #BH7-HM23B

Size

100UG

500UG

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Product Description	Recombinant Human B7-H3 (4Ig)/B7-H3b Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gly27-Thr461.
Product Background	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction.
Product Category	Recombinant Protein / Antibody discovery / CAR-T targets

Protein	B7-H3 (4Ig)/B7-H3b
Synonyms	B7-H3; CD276; PSEC0249;-4Ig-B7-H3; UNQ309; PRO352; B7 homolog 3; CD276
Accession	Q5ZPR3-1
Species	Human
Biotinylated	no
Amino Acid Range	Gly27-Thr461
Molecular Weight	The protein has a predicted MW of 73.4 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human B7-H3 (4Ig), hFc Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-B7-H3 Antibody, hFc Tag with the EC50 of 52.3ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human B7-H3 (4Ig), hFc Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Anti-B7-H3 Antibody, hFc Tag with the EC50 of 52.3ng/ml determined by ELISA.
	Human B7-H3 (4Ig) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human B7-H3 (4Ig) is greater than 95% as determined by SEC-HPLC.

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