Name: Human DLL1/Delta1 Protein (DLL-HM101)
Brand: KactusBio
SKU: DLL-HM101-100UG
Price: 247.5 USD
Availability: InStock

Catalog #DLL-HM101

Size

100UG

500UG

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Product Description	Recombinant Human DLL1/Delta1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln18-Gly540.
Product Background	DLL1, a Notch signaling ligand, is significantly overexpressed in ERα luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor prognosis in ERα luminal breast cancer, but not in other subtypes of breast cancer. In addition, this effect is specific to DLL1, as other Notch ligands (DLL3, JAGGED1, and JAGGED2) do not influence the clinical outcome of ERα patients. DLL1-mediated Notch signaling in breast cancer is important for tumor cell proliferation, angiogenesis, and cancer stem cell function.
Product Category	Recombinant Protein / Antibody discovery

Protein	DLL1/Delta1
Synonyms	H-Delta-1; DLL1; DELTA1; DL1
Accession	NP_005609
Species	Human
Biotinylated	no
Amino Acid Range	Gln18-Gly540
Molecular Weight	The protein has a predicted MW of 57.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in 50mM Tris, 150mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human DLL1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human DLL1 is greater than 95% as determined by SEC-HPLC.