Human FDPS-Protein (FDS-HE001) Summary
Product Description |
Recombinant Human FDPS-Protein is expressed from E.coli with His tag at the N-Terminus.It contains Met1-Lys353. |
Product Background |
Farnesyl pyrophosphate synthase (FPPS, also known as farnesyl diphosphate synthase (FDPS)) is one of the key enzymes involved in the mevalonate pathway and as such is widely expressed. FPPS modulators, specifically FPPS inhibitors, are useful in treating a number of diseases, including bone-related disorders characterized by excessive bone resorption, for example, osteoporosis, cancer metathesis to bone and infectious diseases caused by certain parasites. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human FDPS-Protein (FDS-HE001) Specifications/Details
Protein |
FDPS |
Synonyms |
FPP; FPS; KIAA1293; FPPS |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met1-Lys353 |
Molecular Weight |
The protein has a predicted MW of 41.93 kDa same as Bis-Tris PAGE result. |
Product Tag |
N-His |
Expression System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Human FDPS on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human FDPS is greater than 95% as determined by SEC-HPLC. |
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