Name: Human GBA/glucocerebrosidase Protein (GBA-HM101)
Brand: KactusBio
SKU: GBA-HM101-100UG
Price: 825.0 USD
Availability: InStock

SEC-HPLC chromatogram displaying two peaks around 7.8 and 8.6 minutes, indicating partial aggregation or the presence of multiple protein species.

Human GBA/glucocerebrosidase Protein (GBA-HM101)

Human GBA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human GBA is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Measured by its ability to hydrolyze 4-methylumbelliferyl-beta-D-glucopyranoside. The specific activity is >200 pmol/min/ug.
Amino Acid Range: Ala40-Gln536

Catalog #GBA-HM101

Size

100UG

500UG

Order by 4pm ET for delivery on:

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Human GBA/glucocerebrosidase Protein (GBA-HM101) Summary

Product Description	Recombinant Human GBA/glucocerebrosidase Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala40-Gln536.
Product Background	Glucocerebrosidase (GBA) mutations are the most important genetic risk factor for the development of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase).
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human GBA/glucocerebrosidase Protein (GBA-HM101) Specifications/Details

Protein	GBA
Synonyms	GBA; glucocerebrosidase; Alglucerase; Beta-GC; SGTase; GC; GLUC
Accession	NP_000148.2
Species	Human
Biotinylated	no
Amino Acid Range	Ala40-Gln536
Molecular Weight	The protein has a predicted MW of 56.69 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Activity	Measured by its ability to hydrolyze 4-methylumbelliferyl-beta-D-glucopyranoside. The specific activity is >200 pmol/min/ug.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Human GBA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human GBA is greater than 95% as determined by SEC-HPLC.