Name: Human IGF1R/CD221 Protein (IGF-HM41R)
Brand: KactusBio
SKU: IGF-HM41R-100UG
Price: 346.5 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human IGF1R, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 1.25 ug/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Glu31-Asn932

Catalog #IGF-HM41R

Size

100UG

500UG

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Product Description	Recombinant Human IGF1R/CD221 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus; It contains Glu31-Asn932.
Product Background	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
Product Category	Recombinant Protein / Antibody discovery

Protein	IGF1R/CD221
Synonyms	CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216
Accession	P08069
Species	Human
Biotinylated	no
Amino Acid Range	Glu31-Asn932
Molecular Weight	The protein has a predicted MW of 105.8 kDa (alpha subunit) and 23 kDa (beta subunit). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Bis-Tris PAGE result.
Activity	Immobilized Human IGF1R, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 1.25 ug/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human IGF1R, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 1.25 ug/ml determined by ELISA (QC Test).
	Immobilized Human IGF1R, His Tag at 0.2 ug/ml (100 ul/Well) on the plate. Dose response curve for Anti-IGF1R Antibody, hFc Tag with the EC50 of 10.4 ng/ml determined by ELISA.
	Human IGF1R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human IGF1R is greater than 95% as determined by SEC-HPLC.