Human IL-20RA Protein (IL2-HM2RA) Summary
Product Description |
Recombinant Human IL-20RA Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Val30-Lys250. |
Product Background |
IL-20RA was highly expressed in the tumor tissue of CRC and related to the advanced stage.IL-20RA was involved in regulating oncogenic and immune pathways and affecting the expression of genes related to cell proliferation and immune evasion in CRC.Super-enhancer inhibition by JQ-1 or iBET-151 suppressed the growth of tumor cells and inhibited the expression of IL-20RA. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human IL-20RA Protein (IL2-HM2RA) Specifications/Details
Protein |
IL-20RA |
Synonyms |
IL-20R-alpha; IL-20RA; CRF2-8; IL-20R1; ZcytoR7; FLJ40993 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Val30-Lys250 |
Molecular Weight |
The protein has a predicted MW of 52 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 8.28 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-hFc |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Human IL-20RA, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-20, His Tag with an affinity constant of 8.28 uM as determined in SPR assay (Biacore T200). |
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Human IL-20RA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human IL-20RA is greater than 95% as determined by SEC-HPLC. |
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