Name: Human IL-23R Protein (ILR-HM323)
Brand: KactusBio
SKU: ILR-HM323-100UG
Price: 346.5 USD
Availability: InStock

Express System: HEK293
Product Tag: C-mFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Biotinylated Human IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human IL-23R, mFc Tag with the EC50 of 36.4ng/ml determined by ELISA (QC Test). The affinity constant of 11.09 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Gly24-Gly355

Catalog #ILR-HM323

Size

100UG

500UG

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Product Description	Recombinant Human IL-23R Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Gly24-Gly355.
Product Background	Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R. The binding of IL-23 to its specific cell surface receptor regulates a number of functions, including proliferation and differentiation of cells and secretion of cell factors.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	IL-23R
Synonyms	IBD17; IL-23 R; IL-23 receptor
Accession	Q5VWK5-1
Species	Human
Biotinylated	no
Amino Acid Range	Gly24-Gly355
Molecular Weight	The protein has a predicted MW of 63.7 kDa. Due to glycosylation, the protein migrates to 80-115 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Biotinylated Human IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human IL-23R, mFc Tag with the EC50 of 36.4ng/ml determined by ELISA (QC Test). The affinity constant of 11.09 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-mFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human IL-23R, mFc Tag captured on CM5 Chip via Anti-Mouse Antibody can bind Human IL-23 alpha&IL-12 beta, His-Avi Tag with an affinity constant of 11.09 nM as determined in SPR assay (Biacore T200).
	Immobilized Biotinylated Human IL-23 alpha&IL-12 beta, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human IL-23R, mFc Tag with the EC50 of 36.4ng/ml determined by ELISA (QC Test).
	Human IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human IL-23R is greater than 95% as determined by SEC-HPLC.