Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein (ITG-HM12B)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail

Catalog: ITG-HM12B

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Product Description Recombinant Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail.

Product Background

Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction.

Product Category

Recombinant Protein

Target

Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer
Synonyms ITGA2B&ITGB3; ITGA2B; ITGB3
Accession

Species

Human

Amino Acid Range

Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail
Molecular Weight The protein has a predicted MW of 110.5 kDa (ITGA2B)&81.3 kDa (ITGB3). Due to glycosylation, the protein migrates to 95-115 kDa based on Tris-Bis PAGE result.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human ITGA2B&ITGB3 is greater than 95% as determined by SEC-HPLC.
Human ITGA2B&ITGB3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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