Name: Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein (ITG-HM12B)
Brand: KactusBio
SKU: ITG-HM12B-100UG
Price: 375.0 USD
Availability: InStock

Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein (ITG-HM12B)

Immobilized Abciximab at 1ug/ml (100ul/well) on the plate. Dose response curve for Human ITGA2B&ITGB3, His Tag with the EC50 of 16.7ng/ml determined by ELISA.

Human ITGA2B&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human ITGA2B&ITGB3 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Abciximab at 1ug/ml (100ul/well) on the plate. Dose response curve for Human ITGA2B&ITGB3, His Tag with the EC50 of 16.7ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail

Catalog #ITG-HM12B

Size

100UG

500UG

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Product Description	Recombinant Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail.
Product Background	Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction.
Product Category	Recombinant Protein / Antibody discovery

Protein	Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer
Synonyms	α2Bβ3; ITGA2B&ITGB3; ITGA2B; ITGB3
Accession	P08514-1(ITGA2B)&P05106-1(ITGB3)
Species	Human
Biotinylated	no
Amino Acid Range	Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail
Molecular Weight	The protein has a predicted MW of 110.5 kDa (ITGA2B)&81.3 kDa (ITGB3). Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Abciximab at 1ug/ml (100ul/well) on the plate. Dose response curve for Human ITGA2B&ITGB3, His Tag with the EC50 of 16.7ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Abciximab at 1ug/ml (100ul/well) on the plate. Dose response curve for Human ITGA2B&ITGB3, His Tag with the EC50 of 16.7ng/ml determined by ELISA.
	Human ITGA2B&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human ITGA2B&ITGB3 is greater than 95% as determined by SEC-HPLC.