Name: Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-HM2V3)
Brand: KactusBio
SKU: ITG-HM2V3-100UG
Price: 412.5 USD
Availability: InStock

Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-HM2V3)

Immobilized Human ITGAV&ITGB3, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 16.9ng/ml determined by ELISA.

Human ITGAV&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human ITGAV&ITGB3 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Human ITGAV&ITGB3, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 16.9ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Phe31-Val992(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail

Catalog #ITG-HM2V3

Size

100UG

500UG

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Product Description	Recombinant Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Phe31-Val992(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail.
Product Background	ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
Product Category	Recombinant Protein / Antibody discovery

Protein	Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer
Synonyms	αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3;Integrin alpha V β 3; β3
Accession	P06756-1(ITGAV)&P05106-1(ITGB3)
Species	Human
Biotinylated	no
Amino Acid Range	Phe31-Val992(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail
Molecular Weight	The protein has a predicted MW of 131.90 kDa (ITGAV) & 101.79 kDa (ITGB3). Due to glycosylation, the protein migrates to 140-160 kDa (ITGAV) & 105-130 kDa (ITGB3) based on Bis-Tris PAGE result.
Activity	Immobilized Human ITGAV&ITGB3, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 16.9ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human ITGAV&ITGB3, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 16.9ng/ml determined by ELISA.
	Human ITGAV&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human ITGAV&ITGB3 is greater than 95% as determined by SEC-HPLC.