Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein (ITG-HM4V5)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human ITGAV&ITGB5, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-alpha V Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Phe31-Val992(ITGAV)acidic tail & Gly24-Asn719(ITGB5)basic tail

Catalog: ITG-HM4V5

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Product Description Recombinant Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe31-Val992(ITGAV) acidic tail&Gly24-Asn719(ITGB5) basic tail.

Product Background

Integrin ITGAV & ITGB5 is a type of integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. However, it inhibits angiogenesis. It consists of two components, integrin alpha V and integrin beta 5. Integrin ITGAV & ITGB5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.(Microbial infection)- Integrin ITGAV & ITGB5 acts as a receptor for adenovirus type C.

Product Category

Recombinant Protein

Target

Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer
Synonyms Integrin alpha V beta 5; beta5; alphaV; ITGAV&ITGB5
Accession

Species

Human

Amino Acid Range

Phe31-Val992(ITGAV)acidic tail & Gly24-Asn719(ITGB5)basic tail
Molecular Weight The protein has a predicted MW of 114 kDa (ITGAV)&81.4 kDa (ITGB5). Due to glycosylation,the protein migrates to 85-140 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human ITGAV&ITGB5, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-alpha V Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human ITGAV&ITGB5, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-alpha V Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA.
The purity of-Human ITGAV&ITGB5-is greater than 95% as determined by SEC-HPLC.
Human ITGAV&ITGB5-on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

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