Product Description |
Recombinant Human MERTK/Mer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala21-Ile505. |
Product Background |
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Protein |
MERTK/Mer |
Synonyms |
MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ala21-Ile505 |
Molecular Weight |
The protein has a predicted MW of 53.73 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human MERTK on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human MERTK is greater than 95% as determined by SEC-HPLC. |
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