Name: Non-biotinylated Human Notch 2 Protein (NOT-HM402)
Brand: KactusBio
SKU: NOT-HM402-100UG
Price: 165.0 USD
Availability: InStock

Non-biotinylated Human Notch 2 Protein (NOT-HM402)

Human Notch 2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human Notch 2 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: Leu26-GIn530

Catalog #NOT-HM402

Size

100UG

500UG

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Product Description	Recombinant Human Notch 2 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Leu26-GIn530.
Product Background	Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	Notch 2
Synonyms	AGS2; Notch-2; NOTCH2; N2ECD; HJCYS; N2
Accession	Q04721
Species	Human
Biotinylated	no
Amino Acid Range	Leu26-GIn530
Molecular Weight	The protein has a predicted MW of 57 kDa. Due to glycosylation, the protein migrates to 68-78 kDa based on Bis-Tris PAGE result.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human Notch 2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human Notch 2 is greater than 95% as determined by SEC-HPLC.