Product Description |
Recombinant Human PKC iota Protein is expressed from Baculovirus-Insect Cells with His tag at the C-terminus.It contains Met10-Val596. |
Product Background |
PKClambda/iota belongs to the third group of the PKC family, atypical PKC (aPKC), together with PKCzeta based on its sequence divergence from conventional and novel PKCs observed not only in the N-terminal regulatory domain but also in the kinase domain. Although one of the most distinct features of aPKC is its single, unrepeated cysteine-rich domain, recent studies have revealed that the N-terminal regulatory domain has additional aPKC-specific structural motifs involved in various protein-protein interactions, which are important for the regulation and the subcellular targeting of aPKC. |
Product Category |
Recombinant Protein |
Target |
PKC iota |
Synonyms |
nPKC-iota; PRKCI; DXS1179E; |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Met10-Val596 |
Molecular Weight |
The protein has a predicted MW of 68.78 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
Baculovirus-Insect Cells |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in 50mM Tris, 100mM NaCl, 0.5mM GSH, 0.5mM PMSF, 10% glycerol (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human PKC iota on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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