Name: Mouse Beta Klotho Protein (KLB-MM101)
Brand: KactusBio
SKU: KLB-MM101-100UG
Price: 363.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 90% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Phe53-Pro994

Catalog #KLB-MM101

Size

100UG

500UG

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Product Description	Recombinant Mouse Beta Klotho Protein is expressed from HEK293 with His tag at the C-Terminus; It contains Phe53-Pro994.
Product Background	Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	Beta Klotho
Synonyms	betaKlotho; beta-klotho; BKL; KLB; klotho beta like; Klotho beta; MGC142213;βKlotho; β-klotho; klotho β like; Klotho β
Accession	Q99N32-1
Species	Mouse
Biotinylated	no
Amino Acid Range	Phe53-Pro994
Molecular Weight	The protein has a predicted MW of 109.91 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 90% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human FGFR4, hFc Tag captured on CM5 Chip via Protein A can bind Mouse Beta Klotho, His Tag with an affinity constant of 36.97 nM as determined in SPR assay (Biacore T200).
	Mouse Beta Klotho on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
	The purity of Mouse Beta Klotho Protein is greater than 90% as determined by SEC-HPLC.