SEC-HPLC chromatogram of recombinant protein with a sharp main peak at 7.0 minutes, indicating high monomer purity.
Mouse Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein (ITG-MM1AB)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Tyr27-Thr1129(ITGA2) acidic tail & Gln21-Asp728(ITGB1) basic tail
Catalog #ITG-MM1AB
Regular price $412.50
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Product Description

Recombinant Mouse Integrin alpha 2 beta 1(ITGA2&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus of ITGA2.It contains Tyr27-Thr1129(ITGA2) acidic tail and Gln21-Asp728(ITGB1) basic tail.

Product Background

Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression.HOS cells normally lacking alpha 2 beta 1 integrin were forced to express it, and this prevented the down-regulation in the levels of alpha 1 (I) collagen mRNA when cells were grown inside collagen gels. The data indicate that the level of MMP-1 expression is regulated by the collagen receptor alpha 2 beta 1 integrin.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Protein

Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer

Synonyms

α2β1; ITGA2&ITGB1; ITGA2; ITGB1;

Accession

Species

Mouse

Biotinylated

no

Amino Acid Range

Tyr27-Thr1129(ITGA2) acidic tail & Gln21-Asp728(ITGB1) basic tail

Molecular Weight

The protein has a predicted MW of 126.60 kDa(ITGA2)&82.80 kDa(ITGB1). Due to glycosylation, the protein migrates to 128-138 kDa(ITGA2)&105-115 kDa(ITGB1) based on Bis-Tris PAGE result.

Product Tag

C-His

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Mouse ITGA2&ITGB1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Mouse ITGA2&ITGB1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse ITGA2&ITGB1 is greater than 95% as determined by SEC-HPLC. The purity of Mouse ITGA2&ITGB1 is greater than 95% as determined by SEC-HPLC.

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