Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-MM1V6)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Mouse ITGAV&ITGB6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 41.8ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Phe31-Val988(ITGAV) acidic tail & Gly22-Asn706(ITGB6) basic tail
Catalog #ITG-MM1V6
Regular price $375.00
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Product Description
Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Val988(ITGAV) acidic tail & Gly22-Asn706(ITGB6) basic tail.
Product Background
ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Product Category
Recombinant Protein
Target
Integrin alpha V beta 6 (ITGAV&ITGB6)
Synonyms
ITGAV&ITGB6;Integrin alpha V beta 6
Accession
Species
Mouse
Biotinylated
no
Amino Acid Range
Phe31-Val988(ITGAV) acidic tail & Gly22-Asn706(ITGB6) basic tail
Molecular Weight
The protein has a predicted MW of 111.6 kDa (ITGAV) & 79.2 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-140 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Mouse ITGAV&ITGB6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 41.8ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
C-His
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Mouse ITGAV&ITGB6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 41.8ng/ml determined by ELISA (QC Test).
Immobilized Mouse ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Mouse GARP&Latent TGF beta 1 Complex, His Tag with the EC50 of 89.3ng/ml determined by ELISA.
Mouse ITGAV&ITGB6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.

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