Name: Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-MM1V6)
Brand: KactusBio
SKU: ITG-MM1V6-100UG
Price: 375.0 USD
Availability: InStock

Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-MM1V6)

Immobilized Mouse ITGAV&ITGB6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 41.8ng/ml determined by ELISA (QC Test).

Immobilized Mouse ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Mouse GARP&Latent TGF beta 1 Complex, His Tag with the EC50 of 89.3ng/ml determined by ELISA.

Mouse ITGAV&ITGB6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Mouse ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Mouse ITGAV&ITGB6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 41.8ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Phe31-Val988(ITGAV) acidic tail & Gly22-Asn706(ITGB6) basic tail

Catalog #ITG-MM1V6

Size

100UG

500UG

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Product Description	Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Val988(ITGAV) acidic tail & Gly22-Asn706(ITGB6) basic tail.
Product Background	ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Product Category	Recombinant Protein / Antibody discovery

Protein	Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer
Synonyms	αVβ6; ITGAV&ITGB6;Integrin alpha V beta 6;Integrin alpha V β 6
Accession	P43406(ITGAV)&Q9Z0T9(ITGB6)
Species	Mouse
Biotinylated	no
Amino Acid Range	Phe31-Val988(ITGAV) acidic tail & Gly22-Asn706(ITGB6) basic tail
Molecular Weight	The protein has a predicted MW of 111.6 kDa (ITGAV) & 79.2 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-140 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Mouse ITGAV&ITGB6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 41.8ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Mouse ITGAV&ITGB6, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 41.8ng/ml determined by ELISA (QC Test).
	Immobilized Mouse ITGAV&ITGB6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Mouse GARP&Latent TGF beta 1 Complex, His Tag with the EC50 of 89.3ng/ml determined by ELISA.
	Mouse ITGAV&ITGB6 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Mouse ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.