Mouse TNFRSF12A/TWEAKR Protein (TNF-MM20A)

  • Express System: HEK293
  • Product Tag: N-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: The affinity constant of 0.15 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Glu28-Per80

Catalog: TNF-MM20A

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Product Description Recombinant Mouse TNFRSF12A/TWEAKR Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Glu28-Per80.

Product Background

Thyroid cancer (TC) is the most well-known endocrine neoplasia as well as a common malignant tumor in the head and neck.TNFRSF12A expression may be a potential useful prognostic molecular biomarker of bad survival in thyroid cancer, in addition, PPAR signaling pathway, insulin signaling pathway, mTOR signaling pathway may be the key pathway controlled by TNFRSF12A in thyroid cancer. Further experimental ought to be performed to demonstrate the biologic effect of TNFRSF12A.

Product Category

Recombinant Protein

Target

TNFRSF12A/TWEAKR
Synonyms FGF-inducible 14; Fgfrp2; TNFRSF12A; FN14; CD266; TWEAKR

Gene/Protein ID

Q9CR75

Species

Mouse

Exact Sequence

Glu28-Per80
Molecular Weight The protein has a predicted MW of 32.8 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 0.15 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

N-hFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human TNFSF12, hFc Tag immobilized on CM5 Chip can bind Mouse TNFRSF12A, hFc Tag with an affinity constant of 0.15 nM as determined in SPR assay (Biacore T200).
Mouse TNFRSF12A on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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