Biotinylated Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein (ITG-HM4V5B)
Catalog: ITG-HM4V5B
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Product Description | Recombinant Biotinylated Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe31-Val992(ITGAV) acidic tail&Gly24-Asn719(ITGB5) basic tail. |
Product Background |
Integrin ITGAV & ITGB5 is a type of integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. However, it inhibits angiogenesis. It consists of two components, integrin alpha V and integrin beta 5. Integrin ITGAV & ITGB5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.(Microbial infection)- Integrin ITGAV & ITGB5 acts as a receptor for adenovirus type C. |
Product Category |
Recombinant Protein |
Target |
ITGAV&ITGB5 |
Accession | |
Species |
Human |
Amino Acid Range |
Phe31-Val992(ITGAV)acidic tail & Gly24-Asn719(ITGB5)basic tail |
Molecular Weight | The protein has a predicted MW of 114 kDa (ITGAV)&81.4 kDa (ITGB5). Due to glycosylation, the protein migrates to 85-140 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Biotinylated Human ITGAV&ITGB5, His Tag at 0.5ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-alpha V Antibody, hFc Tag with the EC50 of 15.6ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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