Canine IL-31 Protein (IL3-DM101) Summary
Product Description |
Recombinant Canine IL-31 Protein is expressed from HEK293 with His tag at the N-terminus.It contains Ala27-Gln159. |
Product Background |
Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Canine IL-31 Protein (IL3-DM101) Specifications/Details
Protein |
IL-31 |
Synonyms |
Interleukin-31; IL-31;IL31 |
Accession |
|
Species |
Canine |
Biotinylated |
no |
Amino Acid Range |
Ala27-Gln159 |
Molecular Weight |
The protein has a predicted MW of 16.63 kDa. Due to glycosylation, the protein migrates to 26-36 kDa based on Bis-Tris PAGE result. |
Product Tag |
N-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Canine IL-31 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Canine IL-31 is greater than 95% as determined by SEC-HPLC. |
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