Cynomolgus GDF15 Protein (GDF-CE115)
Cynomolgus GDF15 Protein (GDF-CE115)
Cynomolgus GDF15 Protein (GDF-CE115)
Cynomolgus GDF15 Protein (GDF-CE115)
  • Express System: E.coli
  • Product Tag: N-His
  • Purity: >95% as determined by Bis-Tris PAGE
  • Activity: Immobilized Cynomolgus GDF15, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Cynomolgus GFRAL, His Tag with the EC50 of 39.9 ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Arg193-Val308
Catalog #GDF-CE115
Regular price $315.00
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Product Description
Recombinant Cynomolgus GDF15 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Arg193-Val308.
Product Background
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
Product Category
Recombinant Protein
Target
GDF15
Accession
Species
Cynomolgus
Biotinylated
no
Amino Acid Range
Arg193-Val308
Molecular Weight
The protein has a predicted MW of 14.15 kDa. The protein migrates to 15-18 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Cynomolgus GDF15, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Cynomolgus GFRAL, His Tag with the EC50 of 39.9 ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
N-His
Express System
E.coli
Purity
>95% as determined by Bis-Tris PAGE
Endotoxin
Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in 50mM HAc (pH 2.9). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 50mM HAc (pH 2.9).
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Cynomolgus GDF15, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylated Cynomolgus GFRAL, His Tag with the EC50 of 39.9 ng/ml determined by ELISA (QC Test).
Immobilized Cynomolgus GDF15, His Tag at 0.2 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-GDF15 Antibody, hFc Tag with the EC50 of 6.1 ng/ml determined by ELISA.
Cynomolgus GDF15 on Bis-Tris PAGE under reduced (R) condition and Non reducing (N) condition. The purity is greater than 95%.

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