Name: Cynomolgus PRLR Protein (PLR-CM101)
Brand: KactusBio
SKU: PLR-CM101-100UG
Price: 315.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus PRLR, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 34.6ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Gln25-Thr236

Catalog #PLR-CM101

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus PRLR Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln25-Thr236.
Product Background	Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers.
Product Category	Recombinant Protein / Antibody discovery

Protein	PRLR
Synonyms	PRL-R; HPRL; MFAB; Prolactin R
Accession	A0A2K5WXK1
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Gln25-Thr236
Molecular Weight	The protein has a predicted MW of 25.75 kDa. Due to glycosylation, the protein migrates to 35-50 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus PRLR, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 34.6ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in 50mM Tris, 150mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus PRLR, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 34.6ng/ml determined by ELISA.
	Cynomolgus PRLR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus PRLR is greater than 95% as determined by SEC-HPLC.