Product Description |
Recombinant Human CCL11 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Gly24-Pro97. |
Product Background |
The chemokine CCL11 (also known as eotaxin-1) is a potent eosinophil chemoattractant that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel diseases. CCL11 released from activated astrocytes triggers oxidative stress via microglial NOX1 activation and potentiates glutamate-mediated neurotoxicity, which may be involved in the pathogenesis of various neurological disorders. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Protein |
CCL11 |
Synonyms |
Eotaxin; C-C motif chemokine 11; Small-inducible cytokine A11; SCYA11; eotaxin-1 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gly24-Pro97 |
Molecular Weight |
The protein has a predicted MW of 9.46 kDa. The protein migrates to 13-15 kDa based on Bis-Tris PAGE result. |
Product Tag |
N-His |
Expression System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in 20mM PB, 500mM NaCl, 200mM L-arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human CCL11 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Human CCL11 is greater than 90% as determined by SEC-HPLC. |
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