Name: Human FOLR4/Juno Protein (FOL-HM1R4)
Brand: KactusBio
SKU: FOL-HM1R4-100UG
Price: 300.0 USD
Availability: InStock

Catalog #FOL-HM1R4

Size

100UG

500UG

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Human FOLR4/Juno Protein (FOL-HM1R4) Summary

Product Description	Recombinant Human FOLR4/Juno Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly20-Ser228.
Product Background	Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor.
Product Category	Recombinant Protein / Antibody discovery / CAR-T targets

Human FOLR4/Juno Protein (FOL-HM1R4) Specifications/Details

Protein	FOLR4/Juno
Synonyms	Folate receptor 4; FR-delta; FR delta; Izumo1r; Folbp3; Juno; FOLR4, LOC390243
Accession	A6ND01-1
Species	Human
Biotinylated	no
Amino Acid Range	Gly20-Ser228
Molecular Weight	The protein has a predicted MW of 25 kDa. Due to glycosylation, the protein migrates to 30-35 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human FOLR4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Human FOLR4 is greater than 95% as determined by SEC-HPLC.