Name: Non-biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447)
Brand: KactusBio
SKU: ITG-HM447-100UG
Price: 462.0 USD
Availability: InStock

Non-biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447)

Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test).

Immobilized Human ITGA4&ITGB7, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human MADCAM1, hFc Tag with the EC50 of 5.5ug/ml determined by ELISA.

Human ITGA4&ITGB7 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

Loaded Anti-ITGA4 Antibody, hFc Tag on ProA-Biosensor can bind Human ITGA4&ITGB7, His-Avi Tag with an affinity constant of 1.04 nM as determined in BLI assay (Gator® Prime).

The purity of-Human ITGA4&ITGB7 is greater than 90% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test). See testing image for detail.
Amino Acid Range: Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail

Catalog #ITG-HM447

Size

100UG

500UG

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Non-biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447) Summary

Product Description	Recombinant Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of ITGA4.It contains Tyr34-Thr977(ITGA4) acidic tail and Glu20-His723(ITGB7) basic tail.
Product Background	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Non-biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447) Specifications/Details

Protein	Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer
Synonyms	Integrin alpha 4 beta 7; beta7; alpha 4; LPAM; ITGA4&ITGB7;Integrin alpha 4 β 7; β7
Accession	P13612-1(ITGA4)&P26010-1(ITGB7)
Species	Human
Biotinylated	no
Amino Acid Range	Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail
Molecular Weight	The protein has a predicted MW of 112.5 kDa (ITGA4) & 81.3 kDa (ITGB7). Due to glycosylation,the protein migrates to 70 kDa, 80 kDa, 100-120 kDa and 130-150 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human ITGA4&ITGB7, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA (QC Test).
	Immobilized Human ITGA4&ITGB7, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human MADCAM1, hFc Tag with the EC50 of 5.5ug/ml determined by ELISA.
	Human ITGA4&ITGB7 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
	Loaded Anti-ITGA4 Antibody, hFc Tag on ProA-Biosensor can bind Human ITGA4&ITGB7, His-Avi Tag with an affinity constant of 1.04 nM as determined in BLI assay (Gator® Prime).
	The purity of-Human ITGA4&ITGB7 is greater than 90% as determined by SEC-HPLC.