Name: Human Latent Activin A Protein (ACV-HM101)
Brand: KactusBio
SKU: ACV-HM101-100UG
Price: 330.0 USD
Availability: InStock

Dose-response curve showing recombinant human latent Activin A activity based on RFU versus protein concentration (ng/ml).

Human Latent Activin A Protein (ACV-HM101)

Human Latent Activin A on Bis-Tris PAGE under reduced (R) condition. The purity is greater than 95%.

Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50-for this effect is 30-40 ng/mL.

Express System: HEK293
Product Tag: N-His
Purity: > 95% as determined by Bis-Tris PAGE
Amino Acid Range: Ser21-Ser426

Catalog #ACV-HM101

Size

100UG

500UG

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Product Description	Recombinant Human Latent Activin A Protein is expressed from HEK293 with His tag at the N-terminus.It contains Ser21-Ser426.
Product Background	Activin-A, a member of the TGF-β superfamily, Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and two type II receptors which, upon ligand binding, activate their kinase activity, phosphorylate the SMAD2 and 3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and activate or silence gene expression.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	Latent Activin A
Synonyms	INHBA; Activin A; INHBA; Activin A; Inhibin beta A chain
Accession	P08476
Species	Human
Biotinylated	no
Amino Acid Range	Ser21-Ser426
Molecular Weight	The protein has a predicted MW of 13.0 kDa (mature form) and 32.0 kDa (pro form). Due to glycosylation and interchain disulfide bond, the protein migrates to 15 kDa (mature form) and 40-50 kDa (pro form) under reduced (R) condition based on Bis-Tris PAGE result.
Product Tag	N-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human Latent Activin A on Bis-Tris PAGE under reduced (R) condition. The purity is greater than 95%.
	Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50-for this effect is 30-40 ng/mL.

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