Human PILRA Protein (PRA-HM201) Summary
Product Description |
Recombinant Human PILRA Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln20-Ala197. |
Product Background |
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive performance; Mild Cognitive Impairment (MCI) is instead an objective decline in cognitive performance that does not reach pathology. Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a cell surface inhibitory receptor that was recently suggested to be involved in AD pathogenesis. In particular, the arginine-to-glycine substitution in position 78 (R78, rs1859788) was shown to be protective against AD. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human PILRA Protein (PRA-HM201) Specifications/Details
Protein |
PILRA |
Synonyms |
PILRA; FDF03; PILRalpha; PILR-alpha |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gln20-Ala197 |
Molecular Weight |
The protein has a predicted MW of 47 kDa. Due to glycosylation, the protein migrates to 60-68 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Human PILRA on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human PILRA is greater than 95% as determined by SEC-HPLC. |
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