Mouse Activin RIIA/ACVR2A Protein (ARA-MM12A)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Activity: The affinity constant of 46.06 pM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Ala20-Pro135

Catalog: ARA-MM12A

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Product Description	Recombinant Mouse Activin RIIA/ACVR2A Protein is expressed from HEK293 with His tag at the C-terminus; It contains Ala20-Pro135.
Product Background	Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.
Product Category	Recombinant Protein

Target	Activin RIIA/ACVR2A
Accession	P27038
Species	Mouse
Amino Acid Range	Ala20-Pro135
Molecular Weight	The protein has a predicted MW of 15.06 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 46.06 pM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Mouse Activin RIIA , His Tag captured on CM5 Chip via Anti-His Antibody can bind Human Activin A, No Tag with an affinity constant of 46.06 pM as determined in SPR assay (Biacore T200).
	The purity of Mouse Activin RIIA is greater than 95% as determined by SEC-HPLC.
	Mouse Activin RIIA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.