Name: PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein (MHC-HM418TP)
Brand: KactusBio
SKU: MHC-HM418TP-100UG
Price: 1150.0 USD
Availability: InStock

PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein (MHC-HM418TP)

Express System: HEK293
Product Tag: C-His-Avi
Activity: Immobilized PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Antibody, hFc Tag with the EC50 of 1.67 ug/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVVGAVGVGK peptide

Catalog #MHC-HM418TP

Size

100UG

500UG

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Product Description	Recombinant PE-Labeled Human HLA-A03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. PE-Labeled Human KRAS G12V (HLA-A03:01) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin; It contains Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVVGAVGVGK peptide.
Product Background	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
Product Category	Recombinant Protein

Target	HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer
MHC Form	Tetramer
Allele	HLA-A*03:01
Accession	NP_002107.3(HLA-A*03:01)&P61769(B2M)&VVVGAVGVGK
Species	Human
Biotinylated	no
Amino Acid Range	Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVVGAVGVGK peptide
Activity	Immobilized PE-Labeled Human HLA-A03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-HLA-A03:01&B2M&KRAS G12V (VVVGAVGVGK) Antibody, hFc Tag with the EC50 of 1.67 ug/ml determined by ELISA. See testing image for detail.
Product Tag	C-His-Avi
Fluorophore	PE
Express System	HEK293
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS, 0.2% BSA (pH 7.4).
Stability And Storage	Valid for 6 months from date of receipt when stored at -80°C; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Immobilized PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer, His Tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for Anti-HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Antibody, hFc Tag with the EC50 of 1.67 ug/ml determined by ELISA.

Product Resources

Learn More: MHC Collection Learn More: Peptide-ready MHC Protocol: MHC Staining Case Study: Peptide-ready MHC for TCR Staining Poster: Engineering MHCs as Versatile Reagents