SARS PLpro/papain-like protease Protein (SAR-VE101)
SARS PLpro/papain-like protease Protein (SAR-VE101)
  • Express System: E.coli
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Amino Acid Range: Glu1541-Tyr1859
Catalog #SAR-VE101
Regular price $346.50
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SARS PLpro/papain-like protease Protein (SAR-VE101) Summary

Product Description

Recombinant SARS PLpro/papain-like protease Protein is expressed from E.coli with His tag at the C-terminus.It contains Glu1541-Tyr1859.

Product Background

The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

SARS PLpro/papain-like protease Protein (SAR-VE101) Specifications/Details

Protein
PLpro/papain-like protease
Synonyms
Replicase polyprotein 1a; pp1a; nsp1; PL2-PRO; PL-PRO; Papain-like Protease; Plpro
Accession
Species
SARS
Biotinylated
no
Amino Acid Range
Glu1541-Tyr1859
Molecular Weight
The protein has a predicted MW of 36.91 kDa same as Bis-Tris PAGE result.
Product Tag
C-His
Expression System
E.coli
Purity
> 95% as determined by Bis-Tris PAGE
Endotoxin
Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
Liquid
Shipping
Shipped with dry ice.
Formulation
Supplied as 0.22 um filtered solution in 50 mM Tris, 0.1 % Tween, 150mM NaCl (pH 9.0).
Stability And Storage
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

SARS PLpro on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. SARS PLpro on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
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